The administration of antimicrobial prophylaxis before skin incision (4,229 cases)at cesarean delivery is associated with a reduction in surgical-site infections rather than after cord clamping (4,781 cases ).
The administration of antimicrobials before skin incision had no negative effect on neonatal infection rates, the evaluation of the neonate, or treatment for presumed neonatal infection.
Owens SM Obstet Gynecol 2009;114:573–9
